Both Kaguya and Madara Uchiha are fighting against Kaguya. In the Naruto series, Kaguya is the main antagonist and is fought against by both Madara and the other characters. Madara initially seeks to become the Ten-Tails Jinchuriki in order to fight against Kaguya, but ultimately ends up being manipulated by her. Kaguya is ultimately defeated by Naruto and Sasuke, with the help of other characters, including Madara. **

Both Jigen and Kaguya are powerful characters in the Naruto series, but they have different roles and abilities. Jigen is the vessel for the Otsutsuki clan member, Isshiki, and possesses immense strength and abilities due to this connection. On the other hand, Kaguya is the original Otsutsuki clan member who came to Earth and became the main antagonist in the Naruto series. While both characters are formidable, Kaguya's role as the progenitor of the Otsutsuki clan and her impact on the series make her a more significant and iconic character in the Naruto universe. **

It is difficult to definitively say whether Kaguya is weaker than Madara as their power levels are not directly comparable. Kaguya possesses immense power as the progenitor of chakra and the main antagonist of the Naruto series. Madara, on the other hand, is a highly skilled and powerful Uchiha who has achieved the Rinnegan and has been a formidable opponent for the protagonists. Ultimately, their strength and abilities are different, making it challenging to determine who is weaker or stronger. **

Kaguya Ōtsutsuki is a major antagonist in the Naruto series. She is the mother of Hagoromo Ōtsutsuki (the Sage of Six Paths) and the first person to possess chakra. Kaguya is known for her immense power and her role in creating the Ten-Tails, which led to the formation of the ninja world. She is ultimately defeated by Naruto and Sasuke in the Fourth Great Ninja War. Kaguya's actions and impact on the Naruto universe play a significant role in the series' storyline. **

The Kaguya-sama manga is a Japanese romantic comedy series written and illustrated by Aka Akasaka. It follows the story of two high school students, Kaguya Shinomiya and Miyuki Shirogane, who are both top students and members of the student council. The manga explores their complex relationship as they engage in mind games and schemes to make the other confess their feelings first. The series is known for its witty humor, clever storytelling, and engaging character dynamics. **

It is difficult to determine a clear winner between Goku and Kaguya as they are characters from different anime series with unique abilities and power levels. Goku is known for his incredible strength, speed, and fighting skills as a Saiyan warrior in Dragon Ball Z, while Kaguya is a powerful character from Naruto with abilities like manipulating dimensions and chakra. Ultimately, the outcome of a battle between Goku and Kaguya would depend on various factors such as the setting, circumstances, and plot of the hypothetical matchup. **

It is difficult to definitively say who would win in a battle between Kaguya and Isshiki as both characters possess immense power and abilities. Kaguya is known for her god-like strength and ability to manipulate dimensions, while Isshiki is a highly skilled fighter with advanced techniques and strategic thinking. Ultimately, the outcome of their battle would likely depend on various factors such as their tactics, environment, and level of preparation. **

Kaguya is sealed in Naruto during the Fourth Great Ninja War arc. After being resurrected by Madara Uchiha, Kaguya is eventually sealed by Naruto and Sasuke using the Six Paths Chibaku Tensei, a powerful sealing jutsu. This marks the end of the war and the resolution of the conflict with Kaguya. **